Bacopa

Photo copyright Martin Wall

See also:

• Drug interactions

Common name:

• Brahmi
• water hyssop

Botanical name:

• Bacopa monniera

Parts used and where grown

Bacopa is native to India, where it grows in marshy areas. In the West, bacopa is a familiar water plant used in aquariums. Most parts of the plant have been used traditionally, but modern preparations are extracts of the stem and leaves.

Bacopa has been used in connection with the following conditions (refer to the individual health concern for complete information):

Rating	Health Concerns
	Alzheimer's disease Anxiety ARCD Epilepsy
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.

Historical or traditional use (may or may not be supported by scientific studies)

Since at least the sixth century A.D., bacopa (Brahmi) has been used in Ayurvedic medicine (the traditional medicine of India) as a diuretic and as a tonic for the nervous system and the heart. Specific uses include the treatment of asthma, insanity, and epilepsy.¹

Active constituents

The leaves of bacopa contain saponins, including the bacosides,^{2, 3, 4} which are thought responsible for the therapeutic properties of the herb. In animal studies, both purified bacosides and extracts of bacopa standardized for bacosides have been found to enhance several aspects of mental function and learning ability.^{5, 6, 7} Additional brain effects of bacopa demonstrated in animal research include reduction of both anxiety and depression.^{8, 9} Biochemically, these nervous-system effects have been attributed to an enhancement of the effects of the neurotransmitters acetylcholine and,^{10, 11} possibly, serotonin or GABA (gamma aminobutyric acid).^{12, 13}

Bacopa extracts also appear to have significant antioxidant activity in the brain,¹⁴ and other effects that may help protect brain cells.¹⁵

Animal research has also reported that bacopa extracts can relax the muscles that control the blood vessels, the intestine, and the airways of the respiratory system,^{16, 17, 18, 19} and can help both prevent and heal ulcers in the stomach.²⁰

Traditional herbal references recommend 5 to 10 grams per day of the powdered herb.²¹ Human research has used 300 to 450 mg per day of an extract standardized to contain 55% bacosides.

Bacopa appears to be well tolerated when taken in typical amounts,²² although one double-blind study reported significantly more symptoms of dry mouth, nausea, and muscle fatigue in participants taking bacopa.²³

Are there any drug interactions?

Certain medicines may interact with bacopa. Refer to drug interactions for a list of those medicines.

1. [No author listed]. The Wealth of India: Raw Materials. II-B. New Delhi: Publications and Information Directorate, CSIR, 1950:2-3.
2. Chatterji N, Rastorgi RP, Dhar ML. Chemical examination of Bacopa monniera Wettst. Part I: isolation of chemical constituents. Indian J Chem 1963;1:212.
3. Rastogi S, Pal R, Kulshreshtha DK. Bacoside A3-a triterpenoid saponin from Bacopa monniera. Phytochemistry 1994;36:133-7.
4. Jain P, Kulshreshtha DK. Bacoside A1, a minor saponin from Bacopa monniera. Phytochemistry 1993;33:449-51.
5. Singh HK, Dhawan BN. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmacol 1997;29:S359-S365.
6. Singh HK, Rastogi RP, Srimal RC, Dhawan BN. Effect of bacosides A and B on avoidance responses in rats. Phytother Res 1988;2:70-5.
7. Singh HK, Dhawan BN. Effect of Bacopa monniera Linn. (brahmi) extract on avoidance responses in rat. J Ethnopharmacol 1982;5:205-14.
8. Bhattacharya SK, Ghosal S. Anxiolytic activity of a standardized extract of Bacopa monniera-an experimental study. Phytomedicine 1998;5:77-82.
9. Sairam K, Dorababu M, Goel RK, Bhattacharya SK. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine 2002;9:207-11.
10. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4.
11. Bhattacharya SK, Kumar A, Ghosal S. Effect of Bacopa monniera on animal models of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats. In: Siva Sanka DV, ed. Molecular Aspects of Asian Medicine. New York: PJD Publications, 2000.
12. Ganguly GK, Malhtora CL. Some neuropharmacological and behavioral effects of an activefraction from Herpestis monniera Linn (Brahmi). Indian J Physiol Pharmacol 1967;11:33-43.
13. Dey PK, Datta C. Effect of psychotropic phytochemicals on cerebral amino acid level. Indian J Exp Biol 1966; 4:216-8.
14. Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S. Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus. Phytother Res 2000;14:174-9.
15. Russo A, Borrelli F, Campisi A, et al. Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera. Life Sci 2003;73:1517-26.
16. Dar A, Channa S. Bronchodilatory and cardiovascular effects of an ethanol extract of Bacopa monniera in anaesthetized rats. Phytomedicine 1997;4:319-23.
17. Dar A, Channa S. Relaxant effect of ethanol extract of Bacopa monniera on trachea, pulmonary artery and aorta from rabbit and guinea-pig. Phytother Res 1997;11:323-5.
18. Channa S, Dar A, Yaqoob M, et al. Broncho-vasodilatory activity of fractions and pure constituents isolated from Bacopa monniera. J Ethnopharmacol 2003;86:27-35.
19. Dar A, Channa S. Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea-pig. J Ethnopharmacol 1999;66:167-74.
20. Sairam K, Rao CV, Babu MD, Goel RK. Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine 2001;8:423-30.
21. [No author given]. Indian Herbal Pharmacopoeia, Volume 1. Worli, Mumbai: Indian Drug Manufacturers Association, 1998.
22. Singh HK, Dhawan BN. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmacol 1997;29:S359-S365.
23. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4.

Last Review: 09-07-2006

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