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Alternative Medicine

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Bupropion

 Herbs
 Interactions with Herbs
 Other Interactions
 References


Alternative Medicine
The following information is specific for alternative and complementary medicine. For additional evidence-based information on diseases, conditions, symptoms, diagnosis, treatment and wellness issues, continue searching the Healthwise Knowledgebase.


Also indexed as:

Wellbutrin, Wellbutrin SR, Zyban



Bupropion is used to treat people with depression and to aid in smoking cessation treatment.

Herbs

Summary of Interactions for Bupropion

Depletion or interferenceNone known
Adverse interactionAlcohol
Side effect reduction/preventionNone known
Supportive interaction Yohimbine*
Reduced drug absorption/bioavailabilityNone known


An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Herbs

Yohimbine

A 50-year-old woman who was unresponsive to traditional antidepressant therapy was reported to have a marked and persistent improvement in mood when yohimbine was added to her bupropion therapy.1 Further research is necessary to determine the significance of this finding.

Other Interactions

Alcohol

Unlike most other antidepressant drugs, there is no evidence that alcohol causes significant changes in blood levels of bupropion.2 However, people taking bupropion who are also attempting to discontinue chronic alcohol consumption have been reported to sometimes experience convulsions.3

References

  1. Pollack MH, Hamerness P. Adjunctive yohimbine for treatment in refractory depression. Biol Psychiatry 1993;33:220-1.
  2. Posner J, Bye A, Jeal S, et al. Alcohol and bupropion pharmacokinetics in healthy male volunteers. Eur J Clin Pharmacol 1984;26:627-30.
  3. Storrow AB. Bupropion overdose and seizure. Am J Emerg Med 1994;12:183-4.

Last Review: 09-07-2006

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires August 2007.



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