Carnosine

Carnosine is a small molecule composed of the amino acids, histidine and alanine. It is found in relatively high concentrations in several body tissues-most notably in skeletal muscle, heart muscle, and brain.^{1, 2}

Where is it found?

Dietary sources of preformed carnosine include meat and poultry and fish.

Carnosine has been used in connection with the following conditions (refer to the individual health concern for complete information):

Rating	Health Concerns
	Hepatitis C (zinc-L-carnosine)
	Peptic ulcers Wound healing
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.

Who is likely to be deficient?

Carnosine deficiency may occur in severe protein deficiency and in certain severe genetic disorders characterized by inborn errors in amino acid metabolism.

How much is usually taken?

For eradication of H. pylori, the amount of the zinc carnosine complex used in research studies was 150 mg twice daily. Due to the lack of human clinical trials, recommended levels for other applications are not known at this time.

Are there any side effects or interactions?

Due to the lack of human studies, side effects and interactions are not known.

At the time of writing, there were no well-known drug interactions with carnosine.

1. Quinn PJ, Boldyrev AA, Formazuyk VE. Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med 1992;13:379-444.
2. Bonfanti L, Peretto P, De Marchis S, Fasolo A. Carnosine-related dipeptides in the mammalian brain. Prog Neurobiol 1999;59:333-53.

Last Review: 09-07-2006

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