Stevens-Johnson syndrome (erythema multiforme major) is a rare but
serious condition that causes boil-like sores on the mucous membranes of the
mouth, nose, genitals, and eyelids. A widespread skin rash of irregularly
shaped, flat, purplish red spots also develops, which may be painful.
The skin rash may develop on any part of the body but often begins
on the face, neck, chin, and trunk. Sores that develop on the mucous membranes
weep a thick gray-yellow fluid. When these sores occur on the inside of the
eyelids, the fluid hardens into a crust. When sores occur in the mouth, eating
and drinking can be painful.
Stevens-Johnson syndrome is usually caused by a reaction to a
medication. When this occurs, the person should stop taking the
medication.
The condition may also result from an infection or a vaccination.
Sometimes, Stevens-Johnson syndrome develops as a reaction to donated body
tissues or blood cells, which is called a graft-versus-host disease.
Recovery from Stevens-Johnson syndrome may be slow, taking up to 6
weeks. Treatment includes a soft diet and oral and IV fluids to prevent
dehydration. A doctor will treat mouth and eye sores. In some cases, skin
grafts are needed.
