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Ketolides for pneumonia

 Examples
 How It Works
 Why It Is Used
 How Well It Works
 Side Effects
 What To Think About
 References

Examples

Brand NameChemical Name
Ketektelithromycin

How It Works

Ketolides kill bacteria.

Why It Is Used

Telithromycin can be used for mild-to-moderate pneumonia that you get in your daily life, such as at school or work (community-based pneumonia). It is effective against pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Chlamydophila pneumoniae, and Mycoplasma pneumoniae. It is also effective against some types of Streptococcus pneumoniae that are resistant to other medications.

How Well It Works

The U.S. Food and Drug Administration (FDA) approved telithromycin in 2004, so it has not been widely studied. The research used to gain approval shows that:1

  • About 80% of those using telithromycin were cured. This is about the same as other antibiotics.
  • About 90% of people age 65 or older using telithromycin were cured.

Side Effects

The most common side effects of telithromycin are nausea, headache, dizziness, vomiting, and diarrhea. It may cause vision problems such as blurred vision, difficulty focusing, and seeing double.

Also, there may be a link between Ketek and serious liver problems.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Do not take telithromycin if:

  • You have ever had a severe allergic reaction to telithromycin or to any of the group of antibiotics known as macrolides. These include erythromycin (Ery-Tab, Eryc, EryPed), azithromycin (Zithromax), clarithromycin (Biaxin), and dirithromycin (Dynabac).
  • You are currently taking pimozide (Orap), which is used for tics associated with Tourette's disorder.

Telithromycin may affect other medications. Talk to your doctor if you take:

  • The cholesterol medications simvastatin, lovastatin, or atorvastatin. You should stop treatment with these medications while you are taking telithromycin.
  • Antiarrhythmics medications such as quinidine, procainamide, or dofetilide.
  • Diuretics such as furosemide or hydrochlorothiazide.
  • Any of the following medicines: itraconazole, ketoconazole, midazolam, digoxin, ergot alkaloid derivatives, cyclosporine, carbamazepine, hexobarbital, phenytoin, tacrolimus, sirolimus, metoprolol, theophylline, or rifampin.

Always tell your doctor which medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Talk to your doctor if you:

  • Are pregnant, planning to become pregnant, or are breast-feeding.
  • Have myasthenia gravis, a long-lasting disorder that causes weakness and rapid tiring of muscles.
  • Have had jaundice (yellow color of the skin and/or eyes) while taking telithromycin.

Telithromycin is expensive.

Complete the new medication information form (PDF) Click here to view a form. (What is a PDF document?) to help you understand this medication.

References

Citations

  1. Telithromycin (Ketek) for respiratory infections (2004). Medical Letter on Drugs and Therapeutics, 46(1189): 66–68.


Author: Paul LehnertLast Updated May 6, 2005
Medical Review: Caroline S. Rhoads, MD - Internal Medicine
Kathleen Romito, MD - Family Medicine
Robert L. Cowie, MB, FCP(SA), MD, MSc, MFOM - Pulmonology

This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information. For more information, click here.
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