How It Works
Taken only during the premenstrual phase, spironolactone blocks the
body's use of the
hormone aldosterone, which causes fluid retention in
the body. This has a
diuretic effect, eliminating excess salt and water in
the body.1
Why It Is Used
Spironolactone is sometimes used when bloating, water retention,
and weight gain are the main symptoms of PMS.
How Well It Works
Spironolactone effectively reduces premenstrual bloating, breast
tenderness, and weight gain.1
Side Effects
Side effects of spironolactone use are uncommon but may
include:
- Cramping, diarrhea.
- Drowsiness,
lack of energy.
- Headache, confusion.
- Irregular
menstrual periods.
Side effects go away when use of spironolactone is stopped.
See Drug Reference for a full list of side effects. (Drug Reference
is not available in all systems.)
What To Think About
Before considering spironolactone treatment, see whether reducing
the amount of salt and caffeine in your diet relieves premenstrual bloating,
water retention, or weight gain.
Do not take potassium supplements when using spironolactone-doing
so may result in excessive potassium levels, which can cause lethal heartbeat
problems (arrhythmias).
Complete the new medication information form (PDF) 
(What is a PDF document?)
to help you understand this medication.
References
Citations
Dickerson LM, et al. (2003). Premenstrual syndrome.
American Family Physician, 76(8): 1743-1752.
Credits
| Author | Sandy Jocoy, RN |
| Editor | Kathleen M. Ariss, MS |
| Associate Editor | Tracy Landauer |
| Associate Editor | Pat Truman, MATC |
| Primary Medical Reviewer | Kathleen Romito, MD - Family Medicine |
| Specialist Medical Reviewer | Deborah A. Penava, BA, MD, FRCSC, MPH - Obstetrics and Gynecology |
| Last Updated | June 19, 2008 |
