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Medications that may cause reflux and heartburn

Certain medications may increase abnormal backflow, or reflux, of stomach acid and juices into the esophagus. This reflux occurs when the valve between the lower end of the esophagus and the stomach (the lower esophageal sphincter) does not close tightly enough. These medications may cause reflux by causing the lower esophageal sphincter to relax when it needs to be tightly closed. A common symptom is an uncomfortable feeling of burning, warmth, heat, or pain just behind the breastbone, commonly referred to as heartburn. Medications that may relax the lower esophageal sphincter and increase reflux and heartburn include:

  • Anticholinergic medications, used to treat Parkinson's disease, muscle spasms in the bladder and intestines, and some eye problems. They are also found in some cold medications.
  • Certain hormones such as progesterone, a hormone found in birth control pills.
  • Some heart and blood pressure medications, including calcium channel blockers, alpha-blockers, and beta-blockers.
  • Some medications that act on the nervous system, such as antianxiety medications, anesthetics, and narcotics.
  • Some medicines used to treat osteoporosis.

If you are taking these or any other medications and are having persistent heartburn, talk with your doctor. Do not stop taking any prescribed medications without talking with your doctor.

Credits

AuthorMerrill Hayden
EditorKathleen M. Ariss, MS
Associate EditorMichele Cronen
Associate EditorPat Truman
Primary Medical ReviewerKathleen Romito, MD
- Family Medicine
Specialist Medical ReviewerPeter J. Kahrilas, MD
- Gastroenterology
Last UpdatedApril 18, 2006

Author: Merrill HaydenLast Updated April 18, 2006
Medical Review: Kathleen Romito, MD - Family Medicine
Peter J. Kahrilas, MD - Gastroenterology

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