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Hip Fracture
Topic Overview
What is a hip fracture?
A hip fracture is more
than a broken bone. If you are older, breaking your hip can mean a major change
in your life. You will likely need surgery, and it can take as long as a year
to recover. Activity and
physical therapy
can help you get your strength and
mobility back. You are likely to need support from family or a caregiver as you
recover.
Most hip fractures happen to people who are 65 or older.
If you are in this age group, you need to be extra careful to avoid falls. Most
people break their hip near the upper part of the
thighbone (femur)
. It usually happens near where the thighbone fits into the hip
joint.
What causes hip fractures?
Falls cause most hip
fractures in older adults. As you get older, your bones naturally lose some
strength and are more likely to break, even from a minor fall. Children and
young adults are more likely to break a hip because of a bike or car accident
or a sports injury.
Other things that increase your risk of
breaking your hip include:
- Being female.
- Your family
history—being thin or tall or having family members who had fractures later in
life.
- Poor eating habits. Not getting enough calcium and
vitamin D
can weaken bones.
- Not being
active. Weight-bearing exercise, such as walking, can help keep bones
strong.
- Smoking.
- Medical conditions that cause
dizziness or problems with balance, or conditions such as arthritis that can
interfere with steady and safe movement.
- Taking certain
medicines that may lead to bone loss.
What are the symptoms?
It is hard to miss the
symptoms of a hip fracture. You will most likely have severe pain in your hip
or lower groin area. You probably will not be able to walk or put any weight on
your leg.
These symptoms would be most likely after a fall. But
if you have very thin bones from osteoporosis or another problem, you could
break your hip without falling. In rare cases, people have only thigh or knee
pain. They may be able to walk.
How is a hip fracture diagnosed?
Doctors use
X-rays
to diagnose a broken hip. If your doctor thinks
that you have a fracture but cannot see it on an X-ray, you may need an
MRI
, a
CT scan
, or a
bone scan
.
How is it treated?
You will probably need surgery
to fix your hip. Surgery usually works well, but you will need to be patient.
Getting better will probably take a long time. And you may never be able to get
around as well as you could before.
The type of surgery you have
will depend on where the break is and how bad it is. Your doctor may put metal
screws, a metal plate, or a rod in your hip to fix the break. Or you may need
to have all or part of your hip replaced.
Your doctor will want
you to start moving as soon after surgery as you can. This will help prevent
problems such as pneumonia, blood clots, and bed sores. These things may happen
because you have to stay in bed so long.
After your surgery, it
will be hard for you to do things yourself. You may need to go to a nursing
home or rehabilitation center for a while after your surgery. But the more
active you can be in your care, the faster you will get better.
How can you prevent a hip fracture?
There are many
things you can do to prevent a hip fracture. One of the most important is to
prevent
osteoporosis
. This disease can happen to men or women.
But it is more common in women.
To slow or prevent osteoporosis:
- Get plenty of calcium and vitamin D. Some
women may want to take estrogen after menopause.
- Eat foods high in
calcium. Milk, cheese, yogurt, and other dairy foods have lots of calcium. Dark
green vegetables, some seafood, and almonds are also good. If you want to take
calcium pills, talk to your doctor about how much you need to take.
- Avoid alcohol, and do not smoke.
- Do weight-bearing
exercise that puts pressure on bones and muscles. Walking is a good choice.
Preventing falls is also very important.
- Arrange furniture so that you will not trip
on it.
- Get rid of throw rugs, and move electrical cords out of the
way.
- Be sure you have good lighting where you are
walking.
- Put grab bars in showers and bathtubs.
-
Outside of your home, avoid icy or snowy sidewalks.
- Wear shoes
with sturdy, flat soles.
- Get your eyes checked.
- Avoid too much
alcohol.
- Exercise to help maintain strength and balance.
- Take medicines only as directed and periodically review your
medicines with your primary care doctor, especially if you have more than one
doctor. Some medicines, such as sleeping pills or pain relievers, can increase
your risk of falling.
Frequently Asked Questions
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Learning about fractured hips:
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Being diagnosed:
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Getting treatment:
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Symptoms
The most common symptom of
hip fracture
is severe pain in the hip or lower groin.
Your leg may be rotated to the outside, feel more comfortable when moved away
from your other leg, and be a little shorter than the other leg. You usually
can't walk or even put weight on the injured leg. But in rare cases, there may
be only thigh or knee pain. Walking may still be possible, although painful,
with impacted fractures, where the ball at the top of the thighbone is pushed
down onto the rest of the thighbone.
You typically notice
symptoms after a fall, but a fracture can also occur without a fall, especially
if the bone has been thinned through osteoporosis or other health
conditions.
Exams and Tests
Hip fractures usually are diagnosed
with a physical exam and
X-rays. Signs of
hip fracture
include pain in the groin, thigh, and
knee, being unable to move the leg, and the leg being shorter than the other
and rotated to the outside.
In some cases a fracture is not
visible on the first X-ray. But your doctor will still suspect a hip fracture
because of your hip pain or recent fall. In these cases, your doctor may
suggest other tests, such as:
- An
MRI, which provides better images of bone and soft
tissues.
- A
CT scan, another way of getting more specific images
than X-ray.
- A
bone scan, which involves injecting a dye, then taking
images that show hairline fractures (the bone is cracked, but all pieces are
still in place).
Fractures that were not clearly visible on an X-ray may
show up on an MRI, a CT scan, or a bone scan.
Women who have been
through
menopause
and have a hip fracture also may have
osteoporosis
or be at a higher risk for it. A
bone mineral density test for osteoporosis may provide
early detection and lead to treatment that can help prevent future fractures.
To prevent hip fractures, doctors should ask older people at
least once a year whether they have fallen. If a single fall has occurred, a
simple test should be done to assess the risk of more falls. Your doctor will
watch you stand up from a chair without using your arms, walk several paces,
and return (called the "get up and go test"). If you have any trouble or
unsteadiness, you need further assessment. This includes a detailed medical
history, a review of your medicines, and an examination of vision, balance, and
muscle strength.
Treatment Overview
The goal of treatment for
hip fractures
is to allow you to do, without pain,
most of the things you did before your fracture. The most common and almost
always the best treatment for a hip fracture is surgery. Surgery helps make
sure that the bones are lined up to heal correctly.
After your hip
fracture is diagnosed, you may have a pillow placed under the knee of your
injured leg. Or you may be placed in gentle skin traction to help keep you more
comfortable until surgery.
1
Skin traction attaches a
light weight to your leg using tape, straps, or a special boot. And this weight
provides a constant pull on your leg.
Surgery is done as soon as
possible after a diagnosis of hip fracture, often within 24 hours. Having
surgery right away can help shorten your stay in the hospital and may decrease
pain and complications.
2
But in some cases, surgery
may be delayed for 1 to 2 days for treatment of other medical problems, such as
heart or lung conditions, so surgery will be less risky.
There are
different types of surgery for hip fractures, depending on the location of the
break, the position of the bone fragments, and your age. Surgery for a hip
fracture may include one of the following:
-
Internal fixation.
Internal fixation
involves stabilizing broken bones with surgical screws, rods,
or plates. This type of surgery is usually for people who have fractures in
which the bones can be properly aligned.
-
Hip replacement surgery (arthroplasty). Arthroplasty involves replacing part
or all of the joint with artificial (usually metal) parts. A partial hip
replacement may be done to replace the broken upper part of the thighbone
(femur) with artificial parts. In some cases, a
total hip replacement
can be done if the hip joint area was already damaged before
the fracture by arthritis or an injury and the joint was not working correctly.
Arthroplasty is often done for
femoral neck fractures
when the blood supply to the top of the thighbone is
damaged and there is a chance that the bone might die (
avascular necrosis
). And arthroplasty is often done when the fractured bones
cannot be properly aligned.
Some surgeons are now performing minimally invasive hip
replacement surgery. This means they use a smaller incision in order to
minimize bleeding, healing time, and scar formation. But there may be a greater
chance of complications such as infection, nerve damage, and poor positioning
of the hip replacement components.
3
The surgery looks
promising, but it requires a very skilled and experienced surgeon. Research is
still being done to see how well this surgery works in the long term. Until
risks and long-term benefits are studied, there may be a risk in choosing a
less experienced surgeon to do minimally invasive surgery and leave a smaller
scar, instead of an experienced surgeon who will do a standard
procedure.
Reduction (getting the bone lined up correctly) and
internal fixation (stabilizing broken bones) often are done on younger, active
people. Hip replacement surgery often is done on older, less active adults. In
deciding which of these methods to use for repairing a hip fracture, your
surgeon will consider the type of fracture, your age and activity level, and
also the possible trade-offs. Research on displaced hip fractures (where the
bones are not aligned) shows that, in the long term, total hip replacements may
need to be redone less often than internal fixation, but there is also more
time in surgery, a greater chance of infection, and possibly a greater chance
of death.
4
Surgery usually is the most
effective treatment for a hip fracture, although in most cases you will not
regain all of the mobility that you had before the hip fracture. In general, if
you were healthy and active before the fracture, then you will recover faster
after surgery than a person who was not. If you have other health problems and
have not stayed active, there is a greater chance of
complications after surgery.
In rare
cases, surgery is not done. For example, surgery is not done in people who are
at high risk for complications during or after surgery and who may not benefit
significantly from surgery, such as those who were unable to walk before the
hip fracture and who have minimal pain. In these cases, your doctor will use
medicine to manage your pain.
What to expect after surgery
Right after surgery
for a
hip fracture
, you will have medicine to control pain
and perhaps medicine to prevent blood clots (
anticoagulants
). You may have a
urinary catheter
so you don't have to get out of bed
to urinate. You may also have a compression pump or compression stocking on
your leg, which squeezes your leg to keep the blood circulating and to help
prevent blood clots, and a cushion between your legs to keep your hip in the
correct position. It is not unusual to have an upset stomach or feel
constipated, so talk with your doctor or nurse if you don't feel well.
Your doctor may teach you to do simple breathing exercises to help
prevent congestion in your lungs while your activity level is low. You may also
learn to move your feet up and down to flex your muscles and keep your blood
circulating. And you may begin to learn how to keep your hip in the right
position while you move in bed and get out of bed.
It is very
important to start moving around soon after surgery. This will speed recovery
and reduce complications. On the first day after surgery, you will most likely
be moved out of bed into a chair for a short time, and you will probably begin
light exercises on the second day after surgery.
You will
probably stay in the hospital for about 2 to 4 days after surgery. You may be
moved to an extended-care facility for rehabilitation before going home and so
that you can get help with daily activities, such as bathing on a bath stool.
You will probably need a walking aid—a walker, cane, or crutches—for several
months, and full recovery may take up to a year. For more information on using
walking aids, see:
There are many issues to consider after hip surgery.
Older adults often need extensive care, including
physical therapy
and help with cooking, taking
medicine, and personal care. Anticoagulant medicines are prescribed to reduce
the risk of blood clots and associated
stroke
,
pulmonary embolism
, or
thrombophlebitis
. You will probably keep taking this
medicine until you are walking frequently and well. This often takes at least 3
weeks.
After hip fracture surgery, your doctor will encourage you
to participate in a rehabilitation (rehab) program. Research shows that 6
months of outpatient rehab that includes strength training can improve quality
of life and reduce disability.
5
Following a rehab
program is very important because it will speed up your recovery and allow you
to return to daily activities sooner.
If your hip fracture was
from bone thinning of
osteoporosis
or another cause, your doctor may suggest
that you take medicines such as
bisphosphonates to help prevent another
fracture.
6
After a hip fracture, some
people can never again be as independent as they were before the fracture. They
may need to use a walker or cane to walk. They may need help with daily
activities such as dressing and bathing. And many can no longer live on their
own. It is hard to recover from a hip fracture. So be sure to do all you can to
keep your bones strong and to avoid falls that can lead to a fracture. And if
you do break your hip, work hard to get your strength and mobility back so you
can be as independent as possible.
Prevention
There are steps you can take to help
prevent a
hip fracture
.
Keep your bones strong:
Eat a nutritious diet that includes adequate
amounts of
calcium and
vitamin D. Both are needed for building healthy,
strong bones. The recommended daily calcium intake for adults up to age 50 is
1,000 mg a day. Men and women age 50 and older need 1,200 mg of calcium each
day. The recommended daily intake for vitamin D is 400 to 800 IU a day for
adults up to age 50. If you are age 50 or older, the recommended amount is 800
to 1,000 IU of vitamin D a day.
7
The best source of
vitamin D is exposure to sunlight. Vitamin D is vital for calcium absorption in
bones and to improve muscle strength. One study showed that vitamin D may
reduce an older person's risk of falling by 22%.
8
Studies show that calcium and vitamin D
supplements will not prevent fractures in people who already have risks of
fracture such as low body weight or previous fractures.
9,
10
But getting enough calcium and
vitamin D over your lifetime will help you have stronger bones as you
age.
Exercising and staying active help maintain bone strength.
Weight-bearing exercises such as walking, jogging, and light weight training
help to minimize bone loss. Talk to your doctor about an exercise program that
is right for you. Begin slowly, especially if you have been inactive.
- One study revealed that moderate physical
activity, such as walking, was linked to a substantially lowered number of hip
fractures in postmenopausal women.
11
Talk to your doctor about taking hormone replacement
therapy or other medicines if you are at risk for
osteoporosis
. Some doctors recommend
hormone therapy
for osteoporosis, although its risks
and benefits should be considered. Other medicines such as
bisphosphonates, including alendronate (Fosamax) and
zoledronic acid (Reclast); raloxifene (Evista); and calcitonin (Calcimar or
Miacalcin) are also used to prevent or treat osteoporosis. Studies show that
the bisphosphonates, in particular, significantly reduced the risk of hip
fracture in older women with osteoporosis.
12
For more
information, see the topic
Osteoporosis.
- Don't drink more than 2 alcohol drinks a day
if you are a man, or 1 alcohol drink a day if you are a woman. Drinking more
than this puts you at higher risk for osteoporosis. Alcohol use also raises
your risk of falling and breaking a bone.
- Don't smoke. Smoking puts
you at a higher risk for osteoporosis and increases the rate of bone thinning
after it starts.
For more information, see the topics
Fitness and
Healthy Eating.
Avoid falls:
Almost all hip
fractures in older adults happen because of a fall. Things that increase your
chance of falling include:
- Having poor balance and
coordination.
- Having weakness in one or both
legs.
- Using certain medicines that may cause sleepiness, weakness,
or dizziness.
- Having vision problems.
- Drinking too much
alcohol.
- Feeling confused or having impaired reasoning (caused by
age or conditions such as dementia).
You can reduce your risk for falls by:
- Removing anything in your house that may
cause you to fall. Household hazards that can cause falls include slippery
floors, cords, poor lighting, cluttered walkways, furniture placement that does
not allow a clear pathway for walking, and throw rugs.
- Using
nonslip mats and grab bars in the bathtub and shower.
- Making sure
stairways have handrails. Having rails on both sides of the stairs is best.
Also be sure to turn on the lights when you use the stairs.
- Making
sure you have enough light to see obstacles or pets as you move around your
home.
- Exercising to help maintain strength and balance.
- Taking medicines only as directed and periodically reviewing
your medicines with your primary care doctor, especially if you have more than
one doctor. Some medicines, such as sleeping pills or pain relievers, can
increase your risk of falling.
- Wearing low-heeled shoes that fit
well.
- Using walking aids correctly.
For more information, see the topic
Preventing Falls.
Home Treatment
To help you recover from
hip fracture
surgery, your doctor will recommend a
rehabilitation (rehab) program based on what part of your hip was fractured and
the type of surgery done to repair it. A rehab program will include exercises
to help you regain your strength and your ability to move around, retraining in
simple daily activities, and ideas for staying active. Your doctor may
recommend that you:
- Begin balance training (with a physical
therapist from your hospital or local community center).
- Avoid
movements that may strain your hip (or your new artificial hip parts).
After hip fracture surgery, you may need to learn new ways
to do simple daily activities.
- You will probably need to use a walking aid
(such as a walker, cane, or crutches) for several months. For more information
on how to use walking aids, see:
- Cooking and other simple daily activities, such as bathing, may
be difficult for you to do alone. There are devices such as dressing aids,
raised toilet seats and bath benches, and handrails that may be helpful for
you. Your local chapter of the Arthritis Foundation or a medical supply company
may be able to help you find assistive devices in your area.
- You
may need to make changes to your home to reduce your risk for falls. Household
hazards that can cause falls include slippery floors, cords, poor lighting,
cluttered walkways, furniture placement that does not allow a clear pathway for
walking, and throw rugs. For more information, see:
-
Aging well: Making your home fall-proof.
Take care of yourself:
- Stay active, and exercise a little every
day.
- Eat a nutritious diet.
- Limit alcohol
use.
- Don't smoke.
- Take the correct medicine at the
correct time.
- Get your eyes checked on a regular basis.
Other Places To Get Help
Organizations
|
American Academy of Orthopaedic Surgeons
(AAOS)
|
| 6300 North River Road |
| Rosemont, IL 60018-4262 |
| Phone: |
1-800-346-AAOS (1-800-346-2267) (847) 823-7186 |
| Fax: |
(847) 823-8125 |
| E-mail: |
pemr@aaos.org |
| Web Address: |
www.aaos.org |
| |
|
The American Academy of Orthopaedic Surgeons (AAOS) provides
information and education to raise the public's awareness of musculoskeletal
conditions, with an emphasis on preventive measures. The AAOS Web site contains
information on orthopedic conditions and treatments, injury prevention, and
wellness and exercise.
|
|
|
Centers for Disease Control and Prevention (CDC):
National Center for Injury Prevention and Control
|
| 1600 Clifton Road |
| Atlanta, GA 30333 |
| Phone: |
1-800-CDC-INFO (1-800-232-4636) |
| TDD: |
1-888- 232-6348 |
| E-mail: |
cdcinfo@cdc.gov |
| Web Address: |
www.cdc.gov/injury |
| |
|
This department of the CDC focuses on preventing
injuries and violence and reducing the consequences of injuries and violence.
The Web site has information about injuries, accidents, and situations that can
lead to injuries. It also has prevention ideas and links to other Web sites
with specific information. You can download or order a lot of information from
this Web site.
|
|
|
National Institute of Arthritis and Musculoskeletal and
Skin Diseases (NIAMS), National Institutes of Health
|
| 1 AMS Circle |
| Bethesda, MD 20892-3675 |
| Phone: |
1-877-22-NIAMS (1-877-226-4267) toll-free (301) 495-4484 |
| Fax: |
(301) 718-6366 |
| TDD: |
(301) 565-2966 |
| E-mail: |
niamsinfo@mail.nih.gov |
| Web Address: |
www.niams.nih.gov |
| |
|
The National Institute of Arthritis and Musculoskeletal
and Skin Diseases (NIAMS) is a governmental institute that serves the public
and health professionals by providing information, locating other information
sources, and participating in a national federal database of health
information. NIAMS supports research into the causes, treatment, and prevention
of arthritis and musculoskeletal and skin diseases and supports the training of
scientists to carry out this research.
The NIAMS Web site provides
health information referrals to the NIAMS Clearinghouse, which has information
packages about diseases.
|
|
|
National Osteoporosis Foundation
(NOF)
|
| 1232 22nd Street NW |
| Washington, DC 20037-1292 |
| Phone: |
(202) 223-2226 |
| Web Address: |
www.nof.org |
| |
|
The National Osteoporosis Foundation (NOF) funds research and
publishes educational material about osteoporosis for consumers and health
professionals. The NOF also provides information about bone density testing
sites, new treatment, and local groups interested in osteoporosis. The
foundation's mission is to prevent osteoporosis, to promote lifelong bone
health, to help improve the lives of those affected by osteoporosis and related
fractures, and to find a cure.
|
|
References
Citations
-
Smith WR, et al. (2006). Musculoskeletal trauma
surgery. In HB Skinner, ed., Current Diagnosis and Treatment in Orthopedics, 4th ed., pp. 81–162. New York: Lange Medical
Books/McGraw-Hill.
-
Orosz GM, et al. (2004). Association of timing of
surgery for hip fracture and patient outcomes. JAMA,
291(14): 1738–1743.
-
Howell JR, et al. (2004). Minimally invasive hip
replacement: Rationale, applied anatomy, and instrumentation. Orthopedic Clinics of North America, 35(2):
107–118.
-
Bhandari M, et al. (2003). Internal fixation compared
with arthroplasty for displaced fractures of the femoral neck. Journal of Bone and Joint Surgery,
85-A(9):1673–1681.
-
Binder EF, et al. (2004). Effects of extended
outpatient rehabilitation after hip fracture: A randomized controlled trial.
JAMA, 492(7): 837–846.
-
Qaseem A, et al. (2008). Pharmacologic treatment of
low bone density or osteoporosis to prevent fractures: A clinical practice
guideline from the American College of Physicians. Annals of Internal Medicine, 149(6): 404–415.
-
National Osteoporosis Foundation (2008).
Prevention. Available online:
www.nof.org/prevention/index.htm.
-
Bischoff-Ferrari HA, et al. (2004). Effect of vitamin
D on falls: A meta-analysis. JAMA, 291(16):
1999–2006.
-
Porthouse J, et al. (2005). Randomised controlled
trial of calcium and supplementation with cholecalciferol (vitamin
D3) for prevention of fractures in primary care.
BMJ, 330(7498): 1003.
-
Grant AM, et al. (2005). Oral vitamin D3 and calcium
for secondary prevention of low-trauma fractures in elderly people (randomised
evaluation of calcium or vitamin D, RECORD): A randomised placebo-controlled
trial. Lancet, 365(9471): 1621–1628.
-
Feskanich D, et al. (2002). Walking and leisure-time activity and risk of hip fracture in postmenopausal women. JAMA, 288(18): 2300–2306.
-
Ettinger MP (2003). Aging bone and osteoporosis:
Strategies for preventing fractures in the elderly. Archives of Internal Medicine, 163(18): 2237–2246.
Other Works Consulted
-
American Academy of Orthopaedic Surgeons and American
Academy of Pediatrics (2005). Fracture of the proximal femur. In LY Griffin,
ed., Essentials of Musculoskeletal Care, 3rd ed., pp.
423–427. Rosemont, IL: American Academy of Orthopaedic Surgeons.
-
American Academy of Orthopedic Surgeons (2007).
Minimally Invasive Hip Replacement. Available online:
http://orthoinfo.aaos.org/topic.cfm?topic=A00404&return_link=0.
-
Fiechtner JJ (2003). Hip fracture prevention.
Postgraduate Medicine, 114(3): 22–32.
-
Goldstein WM, Branson JJ (2004). Posterior-lateral
approach to minimal incision total hip arthroplasty. Orthopedic Clinics of North America, 35(2): 131–136.
-
Mercier LR (2000). Fractures of the hip.
In Practical Orthopedics, 5th ed., pp. 172–176. St. Louis: Mosby.
-
Morris AH, Zuckerman JD (2002). National consensus conference on improving the continuum of care for patients with hip fracture. Journal of Bone and Joint Surgery, 84-A(4): 670–674.
-
Oliver D, et al. (2007). Hip fracture, search date
January 2007. Online version of Clinical Evidence (10):
1110.
Credits
|
Author
|
Shannon Erstad, MBA/MPH |
|
Editor
|
Kathleen M. Ariss, MS |
|
Associate Editor
|
Pat Truman, MATC |
|
Primary Medical Reviewer
|
William M. Green, MD - Emergency Medicine |
|
Specialist Medical Reviewer
|
Kenneth J. Koval, MD - Orthopedic Surgery, Orthopedic Trauma |
|
Last Updated
|
May 27, 2009 |
Last Updated:May 27, 2009
Smith WR, et al. (2006). Musculoskeletal trauma
surgery. In HB Skinner, ed., Current Diagnosis and Treatment in Orthopedics, 4th ed., pp. 81–162. New York: Lange Medical
Books/McGraw-Hill.
Orosz GM, et al. (2004). Association of timing of
surgery for hip fracture and patient outcomes. JAMA,
291(14): 1738–1743.
Howell JR, et al. (2004). Minimally invasive hip
replacement: Rationale, applied anatomy, and instrumentation. Orthopedic Clinics of North America, 35(2):
107–118.
Bhandari M, et al. (2003). Internal fixation compared
with arthroplasty for displaced fractures of the femoral neck. Journal of Bone and Joint Surgery,
85-A(9):1673–1681.
Binder EF, et al. (2004). Effects of extended
outpatient rehabilitation after hip fracture: A randomized controlled trial.
JAMA, 492(7): 837–846.
Qaseem A, et al. (2008). Pharmacologic treatment of
low bone density or osteoporosis to prevent fractures: A clinical practice
guideline from the American College of Physicians. Annals of Internal Medicine, 149(6): 404–415.
National Osteoporosis Foundation (2008).
Prevention. Available online:
www.nof.org/prevention/index.htm.
Bischoff-Ferrari HA, et al. (2004). Effect of vitamin
D on falls: A meta-analysis. JAMA, 291(16):
1999–2006.
Porthouse J, et al. (2005). Randomised controlled
trial of calcium and supplementation with cholecalciferol (vitamin
D3) for prevention of fractures in primary care.
BMJ, 330(7498): 1003.
Grant AM, et al. (2005). Oral vitamin D3 and calcium
for secondary prevention of low-trauma fractures in elderly people (randomised
evaluation of calcium or vitamin D, RECORD): A randomised placebo-controlled
trial. Lancet, 365(9471): 1621–1628.
Feskanich D, et al. (2002). Walking and leisure-time activity and risk of hip fracture in postmenopausal women. JAMA, 288(18): 2300–2306.
Ettinger MP (2003). Aging bone and osteoporosis:
Strategies for preventing fractures in the elderly. Archives of Internal Medicine, 163(18): 2237–2246.
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